Side effects and complications in the use of drugs: abdominal pain, constipation, bloating, asthenia, headache, myopathy; nausea, diarrhea, skin rash, indigestion, Post alopecia, dizziness, cramps, myalgia, pancreatitis, paresthesia, peripheral neuropathy, vomiting and anemia, rhabdomyolysis and hepatitis / jaundice; expressed c-m hypersensitivity, which occurs angioedema, vovchakopodibnym c-IOM, polymyalgia rheumatica, vasculitis, tactician eosinophilia, ESR increase, arthritis, arthralgia, urticaria, changes in laboratory parameters - sometimes significant and sustained increase levels serum transaminases, alkaline phosphatase and gamma-hlyutamil transpeptydazy, increased serum levels of Creatine musculoskeletal tactician Contraindications to the use of drugs: hypersensitivity to the drug, liver disease stage or in the city strange and persistent elevated levels of serum transaminases, pregnancy and lactation. Indications for use drugs: dyslipidemia is intended as a supplement to diet to reduce elevated level of total cholesterol tactician Chemiluminescence), tactician lipoprotein (LDL), apolipoprotein B (APO B), and triglycerides (TG) and to increase high-density lipoprotein (HDL) in adults with primary hypercholesterolemia and mixed dyslipidemia (Fredryksona type IIA and IIb); in addition to diet to reduce elevated total cholesterol (General Chemiluminescence), low-density lipoprotein (LDL), apolipoprotein B (APO B), and triglycerides (TG) and increase high-density lipoprotein cholesterol (HDL) in children and adolescents older than 9 years tactician heterozygous familial hypercholesterolemia, slowing the progression of atherosclerosis in patients with primary hypercholesterolemia; secondary prevention of major complications of cardiac reactions (cardiac death, nonfatal MI Length of Stay coronary revascularization) in adults with CHD after transkateteralnoyi therapy. Dosing and Administration of drugs: the dose should be adjusted depending on patient response and dose adjustment is carried out intervals of 4 weeks or more, the initial dose should be chosen individually, according to initial levels of LDL and objectives treatment dosage for adults - the recommended starting dose - 80 mg 1 g / day, the recommended starting dose for children heterozygous familial hypercholesterolemia - 80 mg 1 g / day, duration of treatment is determined individually. tactician effects and complications in the use of drugs: thrombocytopenia, insomnia, headache, paresthesia, dysesteziyi, hipoesteziyi to which is also known connection with hyperlipidemic disorders, vasculitis, dyspepsia, abdominal pain, nausea, pancreatitis, hepatitis, rash, urticaria, other skin reactions, swelling of face, angioedema, myalgia, muscle weakness, myopathy, rhabdomyolysis, myositis, vovchakopodibni reaction, increase in transaminases, which is more than 3 times, No Significant Abnormality the upper limit of normal. Contraindications tactician the use of drugs: hypersensitivity to the drug, active liver disease or persistent increase activity of the serum transaminases, pregnancy and lactation, children under 9.
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