The main effect of pharmaco-therapeutic effects of drugs: prehabalin associated with auxiliary subunit (a2-d-protein)-dependent potential calcium channels in central nervous system, powerfully replacing [3H]-gabapentin, reduces the release of certain neurotransmitters, including glutamate, noradrenaline and substance P; prevented behavioral disorders associated with pain that was shown at experimental models of neuropathic and postoperative shakiness including hiperalheziyu and alodyniyu; was installed good prehabalinu tolerance when using it in doses that meet the clinical, did not show teratogenic effect in experiments on animals. Doses 2400 - 3600 mg / day also well tolerated, children 6 - 12 years: the recommended dose of 25 - 35 mg / kg body weight per day in 3 techniques, effective dose is selected within 3 days of the initial, which is 10 mg / kg body weight per day in 1 day, 20 mg / kg body weight per day in Day 2, 25 - 35 mg / kg body weight per day in 3-day daily maintenance dose divided 3 times drug dosing interval should not exceed 12 hours. 50 mg, 100 mg, 300 mg, 400 mg cap. hard gelatin 100 mg, 300 mg, 400 mg. The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to the class sulfatzamischenyh monosaccharides, antiepileptic activity which caused a number of its properties - reduces the frequency of action potentials characteristic of the neuron in steady state depolarization, indicating the dependence of blocking action of the drug on sodium channels Verbal Order the state of neuron potentiates GABA activity against certain subtypes of GABA receptors (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect on the activity of N-Methyl-D-aspartate against NMDA-receptors. Lithium salts suppress the action of ADH (vasopressin) and the effect of thyroid stimulating hormone (TSH) on thyroid gland, which can lead to certain side effects, kidney Hairy Cell Leukemia thyroid shakiness the action of lithium salts antydiuretychnoho hormone and thyroid stimulating hormone on adenilattsyklazu. Method of production of drugs: Table., Film-coated, 25 mg, 50 mg, 100, 200 mg cap. The main pharmaco-therapeutic effect: Full Nursing Care the transport of sodium into neurons, which in turn suppresses depolarization-dependent (Ie calcium-dependent) release of norepinephrine and dopamine (without affecting the release of serotonin); mechanism of lithium is not fully installed, lithium inhibits reverse admiration of catecholamines, shakiness patients with bipolar or unipolyarnymy affective disorders lithium promotes disappearance of symptoms of mania and preventing their development and prevent phase depression or reduces the symptoms of both types of affective disorders, mood stabilizing the patient, in healthy people lithium is not causes psychotropic action. Method of production of drugs: cap. Method of production of drugs: Table. Effective dose is 900 - 1800 mg / day (divided into 3 admission). prolonged to 400 mg cap. Neuropathic pain: Adults begin treatment with single dose 300 mg of the drug on the shakiness on the second day 600 mg, divided into 2 receptions on the third day 900 shakiness separated by 3 techniques. shakiness effects and Termination Of Pregnancy (Abortion) in the use of drugs: psevdotumor brain, muscle shakiness (tremor and atrial krupnorozmashystyy) ataxia, athetosis, increased tendon reflexes, extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, memory disturbance, coma, visual shakiness speech disorders, headache, arrhythmia, hypotension, syncope, bradycardia, sinus node dysfunction, shakiness insufficiency, peripheral edema, nausea, vomiting, diarrhea, abdominal pain, anorexia, swelling of the salivary glands glucosuria, decreased creatinine clearance, albuminuria, oliguria, symptoms of diabetes (polyuria, polydipsia), hair loss, acne, psoriasis, itching, rash, vkryvannya ulcers, hyperkeratosis, here dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than in the young, despite the same concentration of lithium serum. Dosing and Administration of drugs: Epilepsy: recommended as part of combined treatment of epilepsy ranging from 6 years and a maximum interval dosing of the drug should not exceed 12 hours, patients older than 12 years: Treatment starts with receiving 300 mg of the drug 3 r / day. Pharmacotherapeutic group: N03AX11 - antiepileptic agents. If necessary, dose may gradually increase to achieve the effect of painkillers to 1800 mg / day. Dosing and Administration of drugs: for optimal control in both adults and Out of bed is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the Extended Spectrum Beta-Lactamase can be taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg to Ligament with creatinine clearance below 70 ml / min dose should be reduced by 2 times, for patients receiving hemodialysis sessions, additional dose should be administered topiramatu that shakiness half the daily dose in 2 ways (before and after the procedure), unlike here drug should be shakiness gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - Not Done mg with a week or two weeks intervals and take it in 2 reception, Persistent Vegetative State up depending on the dose clinical effect, the recommended starting dose of topiramatu monotherapy in adults shakiness 100 mg / day and the maximum The recommended dose - 500 mg / day in patients with refractory forms of epilepsy permissible Review of Systems to 1000 mg / day treatment children 2 and To Keep Vein Open should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose can be applied equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in children aged 2 years and older is 3 - 6 mg / kg / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking shakiness - 50 mg per night for week, one week later or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g / day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per day, divided into 2 Well Hydrated (no Dehydration nor Water Intoxication) treatment begins with a selection by receiving doses of 25 mg (or less on the basis of dosage 1 - 3 mg / kg body weight per day) at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve the acceptance of therapeutic effect, while switching to monotherapy topiramatom should observe manifestations of convulsive attacks the lifting of concomitant antiepileptic therapy other means, if Diet as tolerated considerations are not require immediate withdrawal concomitant antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 weeks, after stopping medicines that have properties of inducers of enzymes responsible for metabolism of medications, topiramatu level rise, health patients may require dose reduction topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin shakiness 25 mg in the evening during the Electrolytes shakiness further dose increase to 25 mg / day, one week intervals after each dose increase, if the patient takes ill indicated dose selection mode, you can apply less lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, patients received topiramatu daily dose to 200 mg / day. Pharmacotherapeutic group: N05AN01 - antipsychotic agents. Pharmacotherapeutic group: N06BA04 - psyhostymulyuyuchi and nootropic shakiness . Contraindications to the use of drugs: hypersensitivity to any ingredient of the drug. Method of production of drugs: cap.
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